Urgent: Exploit:JS/Blacole.GP

Hi,
I just ran Microsoft Security Essentials and it found Exploit:JS/Blacole.GP on my pc.
Now I googled it and I read a lot of scary things about it.
Hence I am not sure how to proceed. Simply removing it with Security Essentials will probably not solve the problem, right?

I hope there are some people here who have experience with this virus or exploit.

N.b. the threat was found in the folder
file:C:\Users\****\AppData\Local\Microsoft\Windows\Temporary Internet Files\Low\Content.IE5\ME0WIMYV\word_arrangements[1].htm

I am not going to shut down my pc now because I am scared that it won't start again.

I really hope someone can help me to safely remove this virus.

Thanks a lot in advance.

Corradio