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Unable to open .exe files... "The requested resource is in use"

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For the last few weeks or so I have been having the issue where i can't open any exe files. It shows the the path to the file and then says "The requested resource is in use" I attempted to open msconfig and regedit to see if there were any irregularities but obviously those are exe files so they wouldn't open.

I am unable to open DDS even with your previous instructions I still receive the "requested resource" error message.

Hijackthis works but with this error message:
"For some reason your system denied write access to the Hosts file. If any hijacked domains are in this file, HijackThis may NOT be able to fix this.... etc etc"

I was unable to Run as administrator bc then i would get "the requested resource is in use" error again.

I also have an issue with uninstalling programs. Im not sure if this is related to the resource problem or not. I get this error message:

"An error occurred while trying to uninstall _______. It may have already been uninstalled. Would you like to remove __________. from the Programs and Features list?"

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